From the South - On the Ohio Turnpike, use Toledo Exit 5 and go north on I-280 toward Detroit to I-75 North. At exit 41 (Lincoln Park) turn left (north) on Southfield Rd, which becomes Southfield Freeway (M-39). Exit at 8 Mile Rd and continue straight (on service drive) to sign for 9 Mile Rd. Turn left (crossing freeway), then right to the light at 9 Mile Rd. Turn left, the Cathedral is on the left.

From the West - On I-94 East go to Southfield Freeway North (M-39). [NOTE: If coming from West of Ann Arbor take I-94 east to M-14 east (toward Plymouth) to I-96 East toward Detroit, until Southfield Freeway North (M-39)]. Exit at 8 Mile Rd. Continue straight (on service drive) to sign for 9 Mile Rd. Turn left (crossing Freeway), then right to light at 9 Mile Rd. Turn left, the Cathedral is on the left.

From I-96 East take I-696 East to Lodge Freeway (M-10) South. Exit at 9 Mile Rd, At the light, turn right, and the Cathedral is on the left.

From the North & East - On either I-75, Michigan M-53 (Van Dyke) or I-94, take I-696 West to Greenfield Rd exit. Turn left (south) on Greenfield to 9 Mile Rd. Turn right (West). The Cathedral is on the left after the overpass.